Genomics of Gene Expression

Welcome to the ConesaLab website!

Latest papers and news
Surviving the unexpected heat: a not-so-calm June
Athens_ana
May Highlights from our Lab:
Conexion_Julen
El Conesa Lab asiste a la Asamble General de la Conexión BCB
MOSim_paper
MOSim: bulk and single-cell multi-layer regulatory network simulator.
lrgasp
Systematic assessment of long-read RNA-seq methods for transcript identification and quantification
Screenshot 2024-09-15 at 21-29-33 Fig. 1 Overview of SQANTI3
Sqanti3: curation of long-read transcriptomes for accurate identification of known and novel isoforms
TranD
Nucleotide-level distance metrics to quantify alternative splicing implemented in TranD
Research Lines
Long-reads transcriptomics
We are developing methods and software for the analysis of alternative isoform expression and its effect on the phenotype.

Integration of multi-omic data

We have created a wide array of tools for the analysis of multi-omics data including experimental design, removal of batch effects, simulation of datasets, integration, and visualization.

Single-cell and spatial transcriptomics

We are developing cutting edge algorithms to analyze single cell data, taking special focus on the use of long read data. This goes in combination with spatial-transcriptomics, shaping the future of the field.

Resource and community building

We want to provide scientists easy and accessible tools for their research. Thus, we have created tutorials and guidelines to work with our tools.
Our Tools

Our lab develops statistical methods and user-friendly software tools to analyze these multi-omics data. Our most current interest is the application of long reads sequencing technologies for transcriptome analysis and the integration of multi-omics data to model chromatin-metabolome regulation.

Latest News
El Conesa Lab asiste a la Asamble General de la Conexión BCB
La segunda Asamblea General de la Conexión BCB, celebrada en la sede central del CSIC en Madrid, ha sido...
MOSim: bulk and single-cell multi-layer regulatory network simulator.
In this blogpost we present our latest tool, MOSim, developed by Carolina Monzó MOSim, a novel multi-omic...
New paper released in the journal Bioinformatics! ​
8 July, 2024 Priyansh Srivastava, PhD student in the European project INTERCEPT-MDS (https://intercept-mds.eu/)...
Publication of LRGASP Paper in Nature Methods
The Conesa Lab is proud to announce that our collaborative paper from the Long-Read RNA-Seq Genome Annotation...